Gonadotropin hormone preparation (FDA-approved for fertility)
Human menopausal gonadotropin
A fertility hormone preparation containing FSH and LH activity, used to stimulate egg and sperm production in assisted reproduction.
- Evidence:
- Strong human evidence
- Status:
- FDA-approved for specific labeled indications
- Reviewed:
- 2026-08-03
Also known as: Human menopausal gonadotropin, Menotropins
What is Human menopausal gonadotropin?
A fertility hormone preparation containing FSH and LH activity, used to stimulate egg and sperm production in assisted reproduction.
This profile is educational. It organizes publicly discussed research context for Human menopausal gonadotropin and related naming aliases — it is not a treatment guide.
Proposed mechanism
Exogenous FSH/LH activity stimulates ovarian follicular development in women and spermatogenesis support in men.
Mechanism language on PepGuide describes how researchers discuss pathways. Proposed mechanisms can change as evidence evolves.
Current research notes
Human evidence grade: Strong human evidence
Preclinical evidence grade: Strong human evidence
HMG (menotropins) is FDA approved for fertility treatment. Standard in IVF ovarian stimulation protocols. Human evidence is strong within reproductive medicine. Not related to peptide research markets but included as hormone peptide discussed in sexual health/fertility contexts.
Key uncertainties
- Protocol optimization in poor responders
Research areas being studied
- IVF
- Ovulation induction
- Male fertility
Being studied for a topic is not the same as proven benefit in that topic. Prefer primary literature for study design, endpoints, and limitations.
Safety & side-effect notes
Reported or discussed adverse effects
- Abdominal bloating
- Ovarian enlargement
- Headache
Additional risks & considerations
- Ovarian hyperstimulation syndrome
- Multiple pregnancy
- Injection-site reactions
Regulatory status
FDA-approved for specific labeled indications
FDA approved for infertility treatment.
Regulatory framing here is educational and can lag policy changes. Check official sources for current status.
Frequently asked questions
What is Human menopausal gonadotropin?
A fertility hormone preparation containing FSH and LH activity, used to stimulate egg and sperm production in assisted reproduction.
How does Human menopausal gonadotropin work (proposed mechanism)?
Exogenous FSH/LH activity stimulates ovarian follicular development in women and spermatogenesis support in men.
What is Human menopausal gonadotropin being researched for?
Human menopausal gonadotropin has been discussed in research contexts including: IVF, Ovulation induction, Male fertility.
What does current evidence say about Human menopausal gonadotropin?
Strong human evidence. HMG (menotropins) is FDA approved for fertility treatment. Standard in IVF ovarian stimulation protocols. Human evidence is strong within reproductive medicine. Not related to peptide research markets but included as hormone peptide discussed in sexual health/fertility contexts.
What safety considerations are noted for Human menopausal gonadotropin?
Reported or discussed considerations include: Abdominal bloating; Ovarian enlargement; Headache; Ovarian hyperstimulation syndrome; Multiple pregnancy; Injection-site reactions. This is educational information, not medical advice.
Is Human menopausal gonadotropin FDA approved?
FDA-approved for specific labeled indications. FDA approved for infertility treatment.
References & sources
- Practice Committee ASRM (2016). Menotropins in assisted reproductive technology — Fertil Steril. Evidence type: review.
Prefer interactive tools? Open the PepGuide library entry for Human menopausal gonadotropin or ask PepGuide AI.
Educational and research information only. PepGuide does not sell or prescribe peptides, diagnose conditions, or provide personalized medical advice. Evidence summaries may include early-stage, animal, or limited human research — none of that is a substitute for primary literature or clinician guidance.