Tripeptide alpha-MSH fragment (anti-inflammatory research)
Lys-Pro-Val
An anti-inflammatory tripeptide studied for gut and skin inflammation with emerging but limited human data.
- Evidence:
- Early-stage human research
- Status:
- Research-stage
- Reviewed:
- 2026-08-03
Also known as: Lys-Pro-Val, Alpha-MSH fragment
What is Lys-Pro-Val?
An anti-inflammatory tripeptide studied for gut and skin inflammation with emerging but limited human data.
This profile is educational. It organizes publicly discussed research context for Lys-Pro-Val and related naming aliases — it is not a treatment guide.
Proposed mechanism
MC1R-independent anti-inflammatory signaling; inhibits NF-κB and reduces pro-inflammatory cytokine release.
Mechanism language on PepGuide describes how researchers discuss pathways. Proposed mechanisms can change as evidence evolves.
Current research notes
Human evidence grade: Early-stage human research
Preclinical evidence grade: Moderate human evidence
KPV is the C-terminal fragment of alpha-MSH with anti-inflammatory properties in colitis and skin models. Researchers have studied it for IBD and scalp inflammation-related hair loss. Human clinical evidence remains limited. Often discussed for gut healing and inflammatory skin/scalp conditions.
Key uncertainties
- Clinical efficacy in IBD or hair loss
- Systemic vs local effects
Research areas being studied
- Inflammatory bowel disease
- Dermatitis
- Scalp inflammation
Being studied for a topic is not the same as proven benefit in that topic. Prefer primary literature for study design, endpoints, and limitations.
Safety & side-effect notes
Reported or discussed adverse effects
- Insufficient human systematic reporting
Additional risks & considerations
- Limited human safety data
- Unregulated supply
Regulatory status
Research-stage
Regulatory framing here is educational and can lag policy changes. Check official sources for current status.
Frequently asked questions
What is Lys-Pro-Val?
An anti-inflammatory tripeptide studied for gut and skin inflammation with emerging but limited human data.
How does Lys-Pro-Val work (proposed mechanism)?
MC1R-independent anti-inflammatory signaling; inhibits NF-κB and reduces pro-inflammatory cytokine release.
What is Lys-Pro-Val being researched for?
Lys-Pro-Val has been discussed in research contexts including: Inflammatory bowel disease, Dermatitis, Scalp inflammation.
What does current evidence say about Lys-Pro-Val?
Early-stage human research. KPV is the C-terminal fragment of alpha-MSH with anti-inflammatory properties in colitis and skin models. Researchers have studied it for IBD and scalp inflammation-related hair loss. Human clinical evidence remains limited. Often discussed for gut healing and inflammatory skin/scalp conditions.
What safety considerations are noted for Lys-Pro-Val?
Reported or discussed considerations include: Insufficient human systematic reporting; Limited human safety data; Unregulated supply. This is educational information, not medical advice.
References & sources
- Kannenganti M et al. (2017). KPV peptide inhibits NF-kappaB activation in intestinal epithelial cells — Inflamm Bowel Dis. Evidence type: in_vitro.
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Educational and research information only. PepGuide does not sell or prescribe peptides, diagnose conditions, or provide personalized medical advice. Evidence summaries may include early-stage, animal, or limited human research — none of that is a substitute for primary literature or clinician guidance.